Transforming Autoimmune Treatment: Where Precision Meets Possibility

Driving an immune reset through the targeted depletion of pathogenic cells

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ABOUT US

The next wave of precision immunotherapies

Hillstar Bio is shaping a new era in autoimmune disease treatment through precision immunology. We selectively target and deplete pathogenic immune cells while sparing healthy ones, offering the potential for durable relief via an immune reset for patients with autoimmune conditions.

Unlike traditional therapies that broadly suppress the immune system, our targeted approach addresses specific disease mechanisms by eliminating pathogenic cells, reducing the risks associated with chronic broad immunosuppression while potentially delivering deeper, more durable responses with less frequent dosing compared to existing therapies.

We combine scientific expertise in antibody engineering with a disciplined approach, building upon validated modalities and disease-specific genetic markers to de-risk development while identifying patient populations most likely to benefit from our therapies, moving beyond the one-size-fits-all approach of current autoimmune treatments.

pipeline

Delivering precision therapies that drive durable disease remission

We're building a pipeline of precision immunotherapies targeting specific immune-cell subsets in autoimmune diseases. These therapies have the potential to offer an immune reset rather than chronic symptom management, providing flexibility in selecting the optimal discovery approaches for each target, free from the constraints of platform limitations.

HSB-101

AxSpA
Preclinical Development

Our lead program depletes TRBV9+ T cells in axial spondyloarthritis (AxSpA) and other related HLA-B27-mediated immune and inflammatory conditions. By binding to specific pathogenic cells, our antibody therapeutic offers a selective approach to immune modulation that elevates the patient experience with the potential for an immune reset. The Phase 1 HSB-001 is anticipated to initiate in 2026.

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Programs

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LEAD OPTIMIZATION
OUR TEAM

An accomplished team dedicated to advancing precision immunotherapy

Hillstar Bio brings together leading experts in antibody engineering, immunology, and clinical development, and is backed by prominent venture capital firms.

Our leadership team combines deep understanding of immune-cell biology with a proven track record of discovering and developing breakthrough therapies for patients with autoimmune diseases. We're emboldened by science and driven by unmet patient needs, with a shared commitment to transforming autoimmune care through advanced precision immunology approaches that go beyond symptom management to potentially reset the immune system and address the underlying mechanisms of disease.

Robert Mabry Headshot
Robert Mabry, PhD
Chief Executive Officer
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Mitchell Keegan Headshot
Mitchell Keegan, PhD
Chief Development Officer
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Lauren Mifflin Headshot
Lauren Mifflin, PhD, MBA
Chief Operating Officer
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Angel Baez Headshot
Angel Baez
Sr Research Associate
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Samantha Berrick Headshot
Samantha Berrick
Office Manager
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Adam Buzby Headshot
Adam Buzby
Director of Program Management
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Jianwen Feng Headshot
Jianwen Feng
Sr Director, Antibody Research
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Jean Manuel Headshot
Jean Manuel
Lab Manager and Sr Research Associate
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Mark Ng Headshot
Mark Ng
Principal Scientist
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Jessica Ritter Headshot
Jessica Ritter
Sr Scientist
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Gordon Sears Headshot
Gordon Sears
Sr Research Associate
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Douangsone Vadysirisack Headshot
Douangsone Vadysirisack
Head of Autoimmune Biology Research
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Tiansu Wang Headshot
Tiansu Wang
Sr Scientist
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Changai Xu Headshot
Changai Xu
Sr Scientist
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news

The latest news from Hillstar Bio

CAREERS

Become a part of Hillstar Bio

Join us in our mission to transform autoimmune treatment through precision immunology. We're seeking talented individuals who are inspired by the possibility of delivering next-generation precision immunotherapies to patients still struggling with autoimmune diseases.

At Hillstar Bio, you'll be part of a team that values scientific rigor, innovation, and a focus on patients. We offer a collaborative environment where your contributions can directly impact our ability to deliver transformative medicines with the potential to reset the immune system.

Careers Team members
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